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One group demonstrated that FGF21 increased bone resorption and decreased bone mass in mice (321), in part via induction of hepatic insulin-like growth factor binding protein-1 (IGFBP1) (322)

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Although a plethora of tumor cell mechanosensors have been identified, including focal adhesions, ion channels, actin cytoskeleton, nuclear proteins, and transcription factors, more research is needed to uncover how breast cancer cells convert biophysical signals into biochemical cues to mediate short- and long-term mechanoresponses ( Table 5 )

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Abstract Background Phlegm is prevalent symptom in patients with chronic obstructive pulmonary disease (COPD)