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This occurs due to the ability of spermidine to inhibit histone acetyltransferases [131]

Cell Reports Medicine

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DSIP administration did not significantly affect corticotropin-releasing-hormone (CRH)-stimulated or meal-induced ACTH and cortisol secretion, indicating thatcontrary to stress-protective effects reported in some animal studiesDSIP does not measurably blunt the human cortisol response