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GSH activity is facilitated by activation of the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway, releasing Nrf2 that regulates expression of genes controlling antioxidant, inflammatory and immune system responses

Pesticides such as organophosphates and carbamates have been shown to lower glutathione in tissues, leaving cells more vulnerable

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Yet, established clinical markers for AA remain elusive, emphasizing the need for further research in diagnostic and therapeutic modalities