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Threonine fuels glioblastoma through YRDC-mediated codon-biased translational reprogramming

115 ROS enhance the TGF-/Smad2/3 pathway and induce NF-B activation, collectively suppressing antitumor immunity by inhibiting cytotoxic T cells and NK cells, promoting the expansion of Tregs and MDSCs, and upregulating immune checkpoints like PD-1 and PD-L1

Includes titration schedules, clinical trial data, and Canadian sourcing information

10.1016/j.freeradbiomed.2016.09.017 77 GandhiJ.HernandezR

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