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As a novel therapeutic approach, host-directed therapy (HDT) has gained attention as an avenue for improving treatment outcomes of drug-resistant TB and is being increasingly explored as an adjunct TB treatment [3]

443 Furthermore, systemic AAV vector-mediated LAV-BPIFB4 gene transfer has been shown to redirect circulating SnCs to the spleen and increase the activity of immune cells within the spleen, thereby effectively eliminating senescent immune cells