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This is one of the most searched and asked questionsand rightly so

Nature 312:446-448

Acknowledgements This work was supported by Natural Science Foundation of China (No

249 Research has indicated that CTLA-4 blockade can stabilize TregcDC interactions, allowing Tregs to receive enhanced CD28 costimulatory signals and undergo abnormal local expansion, surpassing Teffs and counteracting the therapeutic benefits of anti-CTLA-4