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One possible inhibitor of G6P is a 17-ketosteroid called Dehydroepiandrosterone, which was also shown to improve LV diastolic function ( Oxidative stress generates nitrotyrosine residues in tissue inhibitor of metalloproteinase (TIMPs) which frees active martix metalloproteinase (MMP)

PMID: 42009144 Free Radic Biol Med FMO1 disrupts mitochondrial functional homeostasis through ROS-mediated mechanisms to drive chondrocyte senescence and hypertrophy