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Alteration behavior (%) was calculated as [successive triplet sets(entries into three different arms consecutively)/total number of arms entries 2] 100 59

The pharmacometabolomic approach provided verification of target engagement when using combined treatment with probenecid and NAC in children with severe TBI

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Downregulated low-density lipoprotein receptor (LDLr) gene, increased liver enzymes [alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH)], cholesterol, triglycerides (TG), low-density lipoprotein (LDL), glucose, and total bilirubin