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GPX4 responds to various tissue injuries by inhibiting different cell death pathways, such as apoptosis, pyroptosis, and necroptosis (Canli et al., 2016

Science (1937) 85:3667

Buchanan JL, Rauckhorst AJ, Taylor EB

The absence of observed primary and secondary lesions in Group I that received DMSO treatment possibly is an indication of normalization of the brain tissue or reduction of the severity of the lesions probably due to some improvement as a result of the intervention