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The inclusion of HA facilitated the targeted delivery of LMMH to the tumor site following systemic circulation, resulting in the rapid release of Mn 2+ and LT by exploiting GSH in the TME

In vitro , adequate Se concentrations decreased apoptosis and oxidative stress markers and increased proliferation and testosterone production of sheep Leydig cells by affecting p-ERK1/2 signaling, steroidogenic enzyme activities, and miR-200a/NRF antioxidant pathway (168)

Additionally, magnoflorine can harm the cell membrane of causing nucleic acid leakage from fungal cells, decreasing squalene epoxidase, 14--lanosterol demethylase activities and lowering ergosterol amounts in a pathogens hyphae [175]

Similarly, the timing of intervention, whether administered before, concurrent with cyclophosphamide, may determine the extent of protection conferred, as it can affect the agents ability to precondition tissue, interrupt ongoing damage, or promote recovery

Ethical Statement: This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors