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The Nrf2 pathway, a major antioxidative mechanism in astrocytes, also becomes dysregulated during neurodegeneration

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110 The Schulze-Hardy rule enables colorimetric enzyme detection through strategic modification of substrate electrophoretic properties, such as charge reversal and valence alternation

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However, when glutamate accumulates outside the synapse, it activates extrasynaptic NMDA receptors, which suppress CREB signaling and initiate neurotoxic cascades, in contrast to synaptic NMDA receptors that promote survival and plasticity (128, 129), This receptor-location-dependent signaling shift contributes to dendritic atrophy and functional decline observed in stress-related disorders such as depression