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They concluded: "The new radiographic measurement named RLAD demonstrated high sensitivity and specificity for detecting LAE [left atrial enlargement] with a strong correlation with LA/Ao ratio

Mujagic Z, de Vos P, Boekschoten MV, Govers C, Pieters H-JHM, de Wit NJW, et al

When TDP-43 is mislocalized from the nucleus to the cytoplasm, there is both loss of nuclear function and toxic sequestration of proteins and ribonucleic acids (RNAs) within the aggregates