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Oral Dosing Runs Higher Injectable: 200 to 500mcg per dose Oral: 500 to 1,000mcg per dose, once or twice daily, taken on an empty stomach Higher oral doses are used to make up for the fact that the gut absorbs the compound poorly compared to injections

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doi: 10.1021/ct100578z

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The concept of cognitive reserve highlights this particularly welltwo individuals with the same structural changes in the brain can display very different degrees of cognitive deficit, with a greater cognitive reserve providing greater resilience against structural deterioration 15