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doi: 10.1300/J092v13n01_02 [DOI] [Google Scholar] 69

Mechanism of Action: Octopamine replaces norepinephrine in sympathetic neurons with chronic use of monoamine oxidase inhibitors Dopamine beta-hydroxylase converts tyramine to octopamine Octopamine can be taken up into storage vesicles in nerve terminals, and then be released by nerve stimulation Octopamine exerts only a small effect on postsynaptic receptors compared to norepinephrine (hence the designation false transmitter) Notes: Octopamine typically exists in only trace amounts in the mammalian CNS, but accumulates when MAO is inhibited (e.g

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doi: 10.1186/s40478-017-0416-x 188 HaqueMEAktherMJakariaMKimIAzamSChoiD

Low magnesium specifically impairs repolarisation of cardiac muscle cells, increasing the risk of ectopic beats (premature ventricular contractions) that patients perceive as 'skipped beats' or fluttering