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All mice were kept in a daily cycle of 12 h of light and 12 h of darkness with humidity and temperature controls

These systems are summarized here and their implications are discussed

Funding The present study was supported by grants from the National Institute of Health (NIH): DA044872

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Its relevance to neuropathy is most direct in the metabolic neuropathies, particularly diabetic peripheral neuropathy, where impaired glucose metabolism, insulin resistance, and mitochondrial dysfunction all contribute to nerve damage