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Key Facts Molecular Cause of Regeneration Loss: In aged muscle, HGF is chemically modified by nitration at tyrosine sites Y198 and Y250, preventing it from docking to c-met receptors on resident satellite cells to trigger muscle repair

Future research may focus on developing oral nanodrug delivery systems, the expansion of targeting strategies by leveraging the homing properties of other immune cells to inflammatory sites, the creation of theranostic platforms using natural products or biologics, and employing microfluidic technologies to enable synergistic co-delivery and enhanced efficacy of dual therapeutic agents

Planning oral steroid use around this timeline can minimize the double burden of GI stress and hepatic load during the most difficult period