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Description

ITPPs action appears to be pH-dependent, showing greater activity in acidic, hypoxic environments, such as ischemic myocardium, while having minimal effect in well-oxygenated, alkaline tissues (Figure 2 for details)

doi: 10.3390/molecules27165099 31 DobroslaviE.GarofuliI

[5] The formulation is free of fragrance, parabens, and mineral oil, and the pH is buffered near 5.5 to optimize tretinoin stability while maintaining skin compatibility