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In the brain, many PLP-dependent enzymes are involved in the metabolism of crucial amino acid or amine neurotransmitters such as dopamine, GABA, glycine, glutamate, and 5-hydroxytryptamine

This result supports that vitamin B6 may function as a source for brain therapeutics against excitotoxicity, since the release of glutamate in excess can result in neuronal damage (78)

Evidence-based : Ensuring clinicians understand the difference between serum B12 levels and clinically active B12 stores, and other suitable tests to determine deficiency as well as symptom resolution with sufficiently frequent treatment

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