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Intestinal GLUT1 activation is pivotal for metformin-induced glucose homeostasis Next, we investigated the potential role of GLUT1 inhibition in mediating the glucotonic effects of metformin in vivo

Nature (2018) 563:56468

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Rather, they form a self-amplifying positive feedback loop orchestrated by the COF platform: an improved immune environment enhances treatment efficacy, and stronger therapeutic effects release more immune stimuli