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The fundamental difference between these variants lies in their amino acid sequence, specifically at position 67, where A1 -casein contains histidine, while A2 -casein contains proline [124]

Bhandarkar A, Bhat S, Kapoor N

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Research has found that the activation of NLRP3 is triggered not only by ROS but also influenced by various other factors, such as ATP, intracellular calcium ion concentration, bacterial infections, and other danger signals