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Insulin-like growth factors (IGFs) signaling through the phosphatidylinositol 3-kinase (PI3K/Akt) downstream pathway can protect neurons against LPS excitotoxicity in cell culture and [124, 128,129]

This is consistent with other studies that have noted that C R is not always present within atypical 2-Cys PRXs 41

Another study highlighted the metabolomic changes associated with vitamin B12 deficiency and repletion, showing improvements in markers of mitochondrial function, myelin integrity, and peripheral nerve function after vitamin B12 injections

Malabsorption (insufficient absorption of vitamin B12in the intestine) through, Insufficient production of intrinsic factor (a protein that is formed in the gastric mucosa and isrequiredfor the absorption of vitamin B12), Diseases in the terminal segment of the ileum (part of the small intestine), e.g

Local discomfort or pain: If the vein is inserted or the infusion is administered, local discomfort or pain may occur