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Under hypoxic conditions, HIF-1 stabilization promotes CD39/CD73 expression, leading to increased adenosine production

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Through a distinct mechanism, choline uptake and PC synthesis regulate IL-1 production mediated by NLRP3 inflammasome activation (69) ( Figure 3 )

doi: 10.1007/s13238-010-0004-3 29 HumphreyW.DalkeA.SchultenK

13 Because acyl coenzyme A formed in the endoplasmic reticulum or outer mitochondrial membrane cannot penetrate the inner mitochondrial membrane to the site of fatty acid -oxidation, the acyl group must be transferred from coenzyme A to carnitine