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Sequential reduction of molecular oxygen (equivalent to sequential addition of electrons) leads to formation of a group of reactive oxygen species: superoxide anion peroxide (hydrogen peroxide) hydroxyl radical The structure of these radicals is shown in the figure below, along with the notation used to denote them

Once freed, Nrf2 translocates to the cell nucleus, where it binds to specific DNA sequences to upregulate the body's own powerful antioxidant enzymes, including Heme Oxygenase-1 (HO-1) and superoxide dismutase

Both helicases showed strong force dependence: at forces above 10 pN, processivity reached the full hairpin length (~1200 bp), whereas at lower forces, processivity decreased sharply to 115.4 58.7 bp for Mer3-WT and to 121.5 77.8 bp for Mer3-8A (Fig