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Neither A 16 nor copper(II) alone was sufficient to produce a detectable fluorescence, but in complex they steadily formed hydrogen peroxide resulting in accumulation of fluorescence over a period of 72 hours in line with previous reports (Fig

Not only does this put mitochondria at risk for Ca 2+ overload leading to excitotoxicity and/or apoptosis, but Ca 2+ that is not buffered may further stimulate nNOS-generated NO

Beyond ADCs, they are also used in peptide-drug conjugates, nucleic acid drug delivery systems (such as siRNA and mRNA), nanomedicine carriers, and prodrug designs, providing critical technological support for precision medicine and cancer therapy