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Together, the parallel observations in swine and human myocardium emphasize that CKD amplifies DM-induced cardiac damage principally via increased oxidative stress and fibrotic remodeling, thereby qualifying these pathways as targets for early intervention in cardiorenal syndrome

3C ) , at least in part, by recovering some genes that were inhibited by ROS treatment, such as the interleukin-3 receptor subunit alpha (IL3RA) ( Fig

Dig Dis Sci 52(2):526530

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