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For patients with uncontrolled hypothyroidism, thyroid hormone replacement should be optimized first, as untreated hypothyroidism can affect glucose metabolism and weight management outcomes

( a ) Complete 2D 1 H- 15 N HSQC spectrum for the experiment shown in main Figs

The patient should be informed of the causative agent(s), once determined, and the reason why they should not be given this in the future should be discussed with them [12]