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However, when administered at the higher doses often explored in preclinical and clinical studies for therapeutic purposes, some side effects have been reported, though these are typically mild and transient

Beyond alcohol and cocaine, the role of GlyT1 inhibition has been investigated in relation to nicotine-seeking behavior

Effects on neuronal potassium (K + ) channelsof which four major groups [voltage-gated K + channels (K V ), Ca 2+ -activated K + channels (K Ca ), two-pore K + channels (K 2P ) and inwardly-rectifying K + channels (K ir )] are expressed in peripheral nervesfurther exacerbate altered neuronal excitability in CIPN