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(6) can be changed to where Ve denotes the volume of the hypothetical effect compartment, Vd the volume of the central compartment, and Ce and C1 drug concentrations in the respective compartments

21,32 In addition, iron is important for normal mitochondrial function, ER stress, DNA impairment and repair, and other cell survival-related enzymatic reactions

ICIE offers a robust, synergistic platform that combines cryosurgery, controlled drug and gene delivery, and immune regulation to address the shortcomings of traditional cancer treatments, presenting a viable avenue for the treatment of aggressive and metastatic malignancies (Fig

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Contributed reagents/materials/analysis tools: PCG CJU CAM