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M1 macrophage polarization is upregulated in IBD

[120] Aronson WJ, Kobayashi N, Barnard RJ, et al

10.1016/j.bpj.2009.09.025 16 CaiM.ZhaoW.ShangX.JiangJ.JiH.TangZ.et al (2012)

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[52] Inheritance and spontaneous mutation [edit] The mutant gene is transmitted with an autosomal dominant pattern of inheritance, but up to 50% of NF-1 cases arise due to spontaneous mutation