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(2013) 136(Pt 4):104866

While less than 20% of children under 10 years of age have cutaneous neurofibromas,14 they generally start appearing after puberty and increase in number as the patient grows older

Additionally, it was indicated that this prostaglandin may have an effect in two directions, namely activation of DP1 receptors, which reduces inflammation and preserves the barrier function of the skin [193], or activation of DP2 receptors, leading to the induction of chemotaxis in leukocytes and promoting the development of inflammation [194]

Thus, the virus can cross the BBB, considering that inflammatory cytokines induce its instability (Daniels et al

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