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Interference with lipid metabolic pathways, including the inhibition of fatty acid -oxidation, similarly depletes DTP populations, underscoring metabolic plasticity as a fundamental vulnerability (47, 48)

FLT3 inhibitor quizartinib induces the upregulation of inflammatory pathways in AML DTP cells and thereby confers susceptibility to anti-inflammatory glucocorticoids (GCs) (Gebru et al., 2020)