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Limited regenerative reserve may contribute to early involvement of specific regions, such as facial muscles in FSHD

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In animal cells, cyclin A-Cdk2 and cyclin E-Cdk2 complexes also utilize RxL-based docking through their 1 helix hydrophobic patches to bind and phosphorylate substrate proteins including Rb, p107, p27, and Cdc6 (Adams et al., 1999