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10.1038/s41598-017-03192-z

5.3 Embryo-Fetal Toxicity Based on findings from animal studies and its mechanism of action, IBRANCE can cause fetal harm when administered to a pregnant woman

In vivo and in vitro results showed that Vit C treatment enhanced pancreatic acinar cell apoptosis, as evidenced by increased expression of Bcl-2, Bcl-XL, and MCL-1 and decreased expression of the apoptosis regulator Bax