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In another embodiment, the invention provides genetic vaccines that include: a) an optimized recombinant binding moiety that comprises a nucleic acid binding domain and a cell-specific ligand, and b) a polynucleotide sequence that comprises a binding site, wherein the nucleic acid binding domain is capable of specifically binding to the binding site

Folate transporters Folate molecules have hydrophilic properties and passive diffusion across cell membranes is minimal

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Leucovorin is very similar to folic acid, says Dr David Mandell, professor of psychiatry at the University of Pennsylvania Perelman School of Medicine

We hope also to further the understanding of the intestinal transport of bacteria and bacterial toxins, in particular since such translocation underlies many important and highly morbid diseases such as sepsis, the systemic inflammatory response syndrome (SIRS) and multiple organ failure (MOF) [4, 5]