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Its well-known adverse events, e.g., interstitial pulmonary fibrosis, seizures, liver veno-occlusive disease, or sinusoidal obstruction syndrome [96] seem to be caused by glutathionyl-tetrahydrothiophene, a metabolite that derives from the irreversible GSH conjugation [97,98]

The impaired synthesis and increased loss and degradation of GSH appear to contribute to a decrease in GSH level in streptozotocin-treated diabetic rat liver [39]

The ligands were bound to D106 according to the crystal structures using the [intermolecular_interactions] block of GROMACS with a bond length of 0.185 nm, a force constant of 10 5 kJ mol 1 nm 2 and bond type 6

Hussain M, Kabir M, and Sood A