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Until now, many histone demethylase inhibitors have been developed, and several have already entered clinical trials, providing a direction for the development of targeted inhibitors

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Estrogen further amplifies hepatic lipogenic capacity and induces the synthesis of yolk precursor lipoproteins, including yolk-targeted very-low-density lipoprotein (VLDLy) and vitellogenin (VTG), thereby synchronizing -3 PUFA metabolism with the reproductive cycle

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