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While many individuals with gallstones remain asymptomatic, over 20% experience symptoms, which vary depending on the location of the stones (2, 3)

doi: 10.1016/j.jff.2024.106476 42

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Notably, most of these natural products have undergone extensive study and validation as drugs 56 or food additives 57 , endowing them with heightened clinical translational value owing to their established safety profiles and druggability, in contrast to unexplored chemical structures

In the process of tumor treatment, inhibition of GPX4 is not always effective, and sometimes drugs resistances occur