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doi: 10.1016/j.freeradbiomed.2012.11.009

Shikonin derivatives inhibited LPS-induced NOS in RAW 264.7 cells via downregulation of MAPK/NF-kappaB signaling

Furthermore, the study demonstrated a specific effect on tau protein hyperphosphorylation, a hallmark of neurodegenerative diseases like Alzheimers disease

In this sense, in a study on a rat model of arthritis, the gel containing CBD reduced the associated inflammation, limb posture score, and thickening of the synovial membrane in a dose-dependent manner [214]

Oxidative stress occurs when there is an imbalance between reactive oxygen species (ROS) and/or reactive nitrogen species and antioxidant capacity