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Peptides for IBS are usually discussed when inflammation or permeability is part of the picture

They found that BPC-157 causes blood vessels to relax and widen, and that this effect depends on the inner lining of the blood vessel and a molecule called nitric oxide

doi:10.1016/j.brainres.2006.07.108

In ex vivo studies using isolated blood vessels, BPC-157 induces vasodilation through increased nitric oxide production, with effects blocked by endothelium removal or eNOS inhibition

Comprehensive safety analysis across over 11,000 participants found that serious adverse events were uncommon, and in cardiovascular outcome trials, serious adverse events were actually lower with semaglutide versus placebo