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The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

LouYWangZXuYZhouPCaoJLiYet alResveratrol prevents doxorubicin-induced cardiotoxicity in H9c2 cells through the inhibition of endoplasmic reticulum stress and the activation of the Sirt1 pathway

The scientific studies of these experimental drugs were never large enough or long enough to establish a clear safety profile, so all we are left with are vague reassurances from tiny studies and testimonials from YouTubers and TikTokers