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Meanwhile, when gut microbiota dysbiosis occurs, it may reduce ferroptosis-protective metabolites (such as 5-HT and 3-HAA) and increase ferroptosis-promoting metabolites (such as TMAO and LPS)

This results in an increase in NAD+ of 10.4% within five days and an almost 30% increase at a 28 day interval

EguchiYHyogoHOnoMMizutaTOnoNFujimotoKet al

(177) found that administering low doses of LPS led to a gradual rise in -syn expression, resulting in intestinal permeability, primarily in the large intestine of mice