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In the TME, MDSCs play a crucial role in the immunosuppressive network, collaborating with M2-like TAMs and CD4 + T cells to produce adverse regulatory impacts on the immune reaction

Thus, there is a growing need to implement innovative strategies for assessing drug efficacy more rapidly and with greater personalization, highlighting the urgent need for advanced in vitro models, including the immune-competent, multi-tissue RA-on-chip platforms, capable of replicating the complex interplay between immune cells and joint-resident stromal components (94, 194, 195)

Experimental Results: Weight and body fat: The simple weight loss group showed an 18% decrease in weight and a 25% decrease in body fat percentage

(ii) spatial metabolomics mapping SCFA gradients against microglial polarization states in peri-infarct regions

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