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Front Physiol 9:

Mechanistically, Rk3 downregulates IDO and Kyn monooxygenase (KMO), while upregulating tryptophan hydroxylase (TPH-1/2), aromatic L-amino acid decarboxylase (AAAD), and kynurenine aminotransferase (KAT) Similar enzyme expression changes are observed in the colon, emphasizing the significance of gutbrain metabolic integration in the antidepressant-like effects of ginsenosides [58]