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Tumor cells can also adapt to KRAS inhibitors by altering cell identity or inducing protein re-localization, resulting in YAP nuclear translocation and activation of YAP-mediated signaling

Similarly, combined analysis of the 165 ROS-associated genes with the 3352 downregulated DEGs revealed 22 candidate ROS-associated downregulated DEGs in COAD, including LRPK2, TLR6, CYBB, ATP7A, HIF1A, CD36, CYP1B1, P2RX7, NOX4, TLR2, SH3PXD2A, BCL2, AGTR1, FBLN5, PDK4, THBS1, ITGAM, PDGFRB, EDN1, LEP, SFTPD, and MAPT

Regular monitoring of renal function and maintaining adequate hydration are important preventive measures

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