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JAMA Netw Open 5(7):1008-1019, 2020

Figures Abstract 1-Methylxanthine (1-MX) is the major metabolite of caffeine and paraxanthine and might contribute to their activity

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The yeast WD40 and WD40 domains are structural homologs with complete conservation of the binding site except for two residues, i.e., His31/Tyr139 in WD40 are replaced by Tyr33/Phe142 in WD40 61,62 (Supplementary Fig