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Certainly, an increase in IGF-1 action is associated with greater risk for neoplastic disease, a link further supported by this study and others targeting IGF-1Rs, but IGF-1 has been paradoxically associated with protection against osteoporosis, type 2 diabetes, cerebrovascular and cognitive decline in pre-clinical studies, as well as in some human epidemiologic studies 12

Such results reinforce the notion that polyphenol-derived prebiotics can regulate pathogenic and commensal bacteria, strengthen hostmicrobe interactions, and ultimately contribute to improved health outcomes ( Similarly, it was found that the administration of syringaresinol modulated the gut microbiota by increasing the relative abundance of the Lactobacillus and Bifidobacterium species while decreasing levels of the potentially harmful Akkermansia genus

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Certificate of Analysis Each batch is tested by an independent third-party laboratory for: Peptide identity verification Purity analysis via HPLC (99%) Microbial contaminant screening Heavy metal analysis Residual solvent testing Key Ingredients Tripeptide-copper complex studied for its ability to modulate over 4,000 human genes

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