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By modulating mitochondrial activity and decreasing the electron transport chains overactivity, it lowers the intracellular generation of ROSs at their source

We designed an antagonist peptide of VEGF-A and VEGF-B reproducing two discontinuous receptor binding regions of VEGF-B (loop 1 and loop3) covalently linked together by a receptor binding region of VEGF-A (loop3)

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doi: 10.3390/ijms22136814 [DOI] [PMC free article] [PubMed] [Google Scholar] 63.Hu C, Yang J, Qi Z, et al

It is also shown to penetrate the ECs in vitro [183]