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GSH is synthesized in the cytosol through two sequential, ATP-dependent enzymatic reactions 19

Therefore, the severity of AD is classified from mild to severe according to various clinical scales such as the Eczema Area and Severity Index (EASI), the Investigator Global Evaluation (IGA), the Three Item Severity Score (TIS), and the SCORing Atopic Dermatitis (SCORAD) scales (7)

Bone marrow aspiration is only recommended in the presence of another associated cytopenia or persistent reticulocytopenia or on suspicion of neoplasia or myelodysplasia (D) (AIEOP 2017) [23]