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Recent studies have demonstrated that patients with PI ZZ genotype exhibit reduced expression of catalase and glutathione reductase, indicating an indirect role of alpha-1 antitrypsin (A1AT) in modulating reactive oxygen species (ROS) and reactive nitrogen species (RNS) levels

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Glutathione itself neutralizes free radicals, recycles antioxidants, is involved in phase 1 and 2 detoxification, helps transport mercury out of the cells and the brain, regulates cell growth, and is vital to mitochondrial and DNA health