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Post-marketing experience with ophthalmic NSAIDs, including ketorolac, suggests that patients with complicated ocular surgery, corneal denervation, corneal epithelial defects, diabetes mellitus, ocular disease affecting the ocular surface (e.g., xerophthalmia, dry eye syndrome), rheumatoid arthritis, or repeat ocular surgeries within a short period of time may be at increased risk for corneal adverse events (corneal thinning, corneal erosion, corneal ulceration, corneal perforation) that may become sight-threatening

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Observational data strongly supports this phenomenon

Nearby organs, such as the pancreas, gall bladder or spleen may need to be removed as well